May 2024
Talamonti E, Davegardh J, Kalinovich A, van Beek S, Dehvari N, Halleskog C, Bokhari MH, Dana S Hutchinson DS, Ham S, Humphrys LJ, Dijon NC, Motso A, Sandstrom A, Zacharewicz E, Mutule I, Suna E, Spura J, Ditrychova K, Stoddart LA, Holliday ND, Wright SC, Lauschke VM, Nielsen S, Scheele C, Cheesman E, Hoeks J, Molenaar P, Summers RJ, Pelcman B, Yakala GK, Bengtsson T.
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis
Mol Metabol. 2024 Jul:85:101931.doi: 10.1016/j.molmet.2024.101931. Epub 2024 May 17. PMID: 38796310
https://doi.org/10.1016/j.molmet.2024.101931
Nov 2023
Jaunsleine K, Supe L, Spura J, van Beek S, Sandström A, Olsen JM, Halleskog C, Bengtsson T, Mutule I, Pelcman B.
Development of novel β2-adrenergic receptor agonists for the stimulation of glucose uptake – The importance of chirality and ring size of cyclic amines
Bioorg Med Chem Lett. 2024 Jan 1:97:129562. doi: 10.1016/j.bmcl.2023.129562. Epub 2023 Nov 13. PMID: 37967654
https://doi.org/10.1016/j.bmcl.2023.129562
Nov 2021
Ekman Ryding A.
A new approach to treat type 2 diabetes – Targeting a non-insulin dependent pathway
Drug Discov Today. 2021 Nov;26(11):2487-2488. doi: 10.1016/j.drudis.2021.07.022. Epub 2021 Jul 30.
https://doi.org/10.1016/j.drudis.2021.07.022
May 2020
Kalinovich A, Dehvari N, Åslund A, van Beek S, Halleskog C, Olsen JM, Forsberg E, Zacharewicz E, Schaart G, Rinde M, Sandström A, Berlin R, Östenson CG, Hoeks J, Bengtsson T.
Treatment with β-2-adrenoceptor agonist stimulates glucose uptake in skeletal muscle and improves glucose homeostasis, insulin resistance and hepatic steatosis in mice with diet-induced obesity
Diabetologia.2020 Aug;63(8):1603-1615. doi: 10.1007/s00125-020-05171-y. Epub 2020 May 29. PMID: 32472192
https://doi.org/10.1007/s00125-020-05171-y
Dec 2019
Olsen JM, Åslund A, Bokhari MH, Hutchinson DS, Bengtsson T.
Acute β-adrenoceptor mediated glucose clearance in brown adipose tissue; a distinct pathway independent of functional insulin signaling.
Mol Metab. 2019 Dec;30:240-249. doi: 10.1016/j.molmet.2019.10.004. Epub 2019 Oct 18. PubMed PMID: 31767175; PubMed Central PMCID: PMC6838983.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838983/
May 2019
Mukaida S, Sato M, Öberg AI, Dehvari N, Olsen JM, Kocan M, Halls ML, Merlin J, Sandström AL, Csikasz RI, Evans BA, Summers RJ, Hutchinson DS, Bengtsson T
BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β(2)-adrenoceptors without causing classical receptor desensitization
Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R666-R677. doi: 10.1152/ajpregu.00285.2018. Epub 2019 Mar 20. PubMed PMID: 30892909
https://journals.physiology.org/doi/full/10.1152/ajpregu.00285.2018?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Feb 2019
Chia LY, Evans BA, Mukaida S, Bengtsson T, Hutchinson DS, Sato M.
Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue.
Br J Pharmacol. 2019 Jul;176(14):2433-2448. doi: 10.1111/bph.14616. Epub 2019 Apr 7. Review. PubMed PMID: 30740664; PubMed Central PMCID: PMC6592864.
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14616
Nov 2018
Br J Pharmacol. 2018 Nov;175(21):4072-4082. doi: 10.1111/bph.14121. Epub 2018 Jan 18. Review. PubMed PMID: 29243229; PubMed Central PMCID: PMC6177610.
Mirabegron: potential off target effects and uses beyond the bladder
. Br J Pharmacol. 2018 Nov;175(21):4072-4082. doi: 10.1111/bph.14121. Epub 2018 Jan 18. Review. PubMed PMID: 29243229; PubMed Central PMCID: PMC6177610
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177610/
Mar 2017
Olsen JM, Csikasz RI, Dehvari N, Lu L, Sandström A, Öberg AI, Nedergaard J, Stone-Elander S, Bengtsson T
β(3)-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway
Mol Metab. 2017 Mar 30;6(6):611-619. doi: 10.1016/j.molmet.2017.02.006. eCollection 2017 Jun. PubMed PMID: 28580291; PubMed Central PMCID: PMC5444022
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444022/
Dec 2014
Sato M, Dehvari N, Oberg AI, Dallner OS, Sandström AL, Olsen JM, Csikasz RI, Summers RJ, Hutchinson DS, Bengtsson T
Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle
Diabetes 2014 Dec;63(12):4115-29. doi: 10.2337/db13-1860. Epub 2014 Jul 9. PubMed PMID: 25008179.
https://diabetes.diabetesjournals.org/content/63/12/4115
Nov 2014
Olsen JM, Sato M, Dallner OS, Sandström AL, Pisani DF, Chambard JC, Amri EZ, Hutchinson DS, Bengtsson T
Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation
J Cell Biol. 2014 Nov 10;207(3):365-74. doi: 10.1083/jcb.201403080. PubMed PMID: 25385184; PubMed Central PMCID: PMC4226734.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226734/
Mar 2012
Dehvari N, Hutchinson DS, Nevzorova J, Dallner OS, Sato M, Kocan M, Merlin J, Evans BA, Summers RJ, Bengtsson T
β(2)-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail
Br J Pharmacol. 2012 Mar;165(5):1442-56. doi: 10.1111/j.1476-5381.2011.01647.x. PubMed PMID: 21883150; PubMed Central PMCID: PMC3372728.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372728/